Lower levels of opioid analgesics happen to be detected in human milk. The developmental and wellness advantages of breastfeeding must be regarded together with the mom's clinical will need for DILAUDID INJECTION and any possible adverse outcomes about the breastfed toddler from DILAUDID INJECTION or from your fundamental maternal issue.
Though really serious, lifetime-threatening, or fatal respiratory depression can manifest Anytime throughout the use of DILAUDID INJECTION, the chance is greatest throughout the initiation of therapy or following a dosage boost.
There is a partnership in between raising hydromorphone plasma focus and escalating frequency of dose-relevant opioid adverse reactions for example nausea, vomiting, CNS consequences, and respiratory melancholy.
The pharmacokinetics of hydromorphone in people with extreme hepatic impairment hasn't been studied. An extra rise in Cmax and AUC of hydromorphone With this team is anticipated and should be taken into consideration when deciding on a beginning dose [see Use in Certain Populations (eight.six)].
Extended use of DILAUDID INJECTION throughout pregnancy can lead to neonatal opioid withdrawal syndrome, which can be existence-threatening Otherwise identified and treated, and demands management In line with protocols produced by neonatology professionals.
You shouldn’t choose hydromorphone or morphine within fourteen times of using a monoamine oxidase inhibitor (MAOI).
five.3 Neonatal Opioid Withdrawal Syndrome Prolonged use of DILAUDID INJECTION through pregnancy may lead to withdrawal during the neonate. Neonatal opioid withdrawal syndrome, not like opioid withdrawal syndrome in Grown ups, might be everyday living-threatening Otherwise identified and addressed, and needs management As outlined by protocols created by neonatology experts.
DILAUDID INJECTION check here may be presented intravenously, but the injection need to be presented extremely gradually. Immediate intravenous injection of opioid analgesics will increase the possibility of side effects for instance hypotension and respiratory depression [see DOSAGE AND ADMINISTRATION].
Alter the dosage to get an proper stability among management of pain and opioid-connected adverse reactions.
Adrenal insufficiency: Conditions of adrenal insufficiency have already been claimed with opioid use, much more usually adhering to increased than just one month of use.
Mainly because elderly individuals usually tend to have diminished renal operate, care should be taken in dose choice, and it might be helpful to observe renal operate.
Each drug might have other drug interactions that will enhance your possibility for major Unwanted effects. Be sure to tell your Health care company about all prescription medicine and about-the-counter items that you’re using.
Reserve concomitant prescribing of DILAUDID Injection and benzodiazepines or other CNS depressants to be used in people for whom alternate remedy possibilities are inadequate.
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